| A | B |
| Conquistador | a Spanish conqueror who sought gold and other riches in the Americas |
| Missionary | a person who tries to spread Christianity to others |
| Viceroy | a governor of Spain’s colonies in the Americas who represented the Spanish king and queen |
| Mercantilism | an economic policy that gives a country sole ownership of the trade occurring in its colonies |
| Smallpox | a deadly virus that causes a high fever and small blisters on the skin |
| Viceroyalty | a territory governed by a viceroy |
| Circumnavigate | to travel completely around Earth |
| Northwest Passage | a passage by water between the Atlantic and Pacific oceans along the northern coast of North America |
| Privateer | an armed but privately owned ship that acts under the authority of a government to participate in warfare |
| Galleon | a large sailing ship used especially by the Spanish in the 16th and 17th centuries |
| Persecute | to punish, particularly because of beliefs or background |
| Watershed | an area of land that includes a particular river or lake and all the bodies of water that flow into it |
| Heretic | a person who holds beliefs different from the teachings of the Catholic Church |