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BIOCHEMISTRY_ DNA

AB
NUCLEOTIDEbuilding block of nucleic acid consists of a base, pentose sugar (ribose or dexyribose) and phosphate
NUCLEOSIDEcombination of pentose sugar and base (no phosphate)
OKAZAKI FRAGMENTSshort segment formed by DNA polymerase in daughter DNA strand that runs in the 3' to 5'
DNA FINGERPRINTSuses PCR to identify individuals based on a set of 13 hereditary traits
VIRUSa small particle containing DNA and RNA in a protein coat that requires a host cell for replication
RETROVIRUSa virus containing RNA as its genetic material and that synthesizes a complementary DNA strand inside a cell
STRUCTURAL GENEa gene that codeS for a structural protein, an enzyme, or an RNA molecule not involved in regulation
MUTATIONa change in the DNA base sequence that may alter the shape and function of a protein
SUBSTITUTION (POINT MUTATION)the substitution of ONE BASE in the DNA template with another
DELETION FRAMESHIFT (mutation)a base is DELETED from the normal order of bases in the template DNA; all triplets shift by one base
INSEERTION FRAMESHIFT (mutation)a base is INSERTED in the normal order of bases in the template DNA; all triplets shift by one base
GENETIC DISEASEa physical malformation or metabolic dysfunction caused by mutation in the bases of DNA
HELICASEseparate double-stranded DNA into single strands allowing each strand to be copied (UNWIND)
mRNA (messenger RNA)produced in the nucleus of the DNA, carries genetic information to the ribosomes for construction of a protein
tRNA (transfer RNA)places a specific amino acid into a peptide chain at the ribosome so a protein can be made
rRNA (ribosomal RNA)most prevalent type of RNA, combines with proteins to make ribosomes
DNAgenetic materials of all cells containing nucleotides with deoxyribose, phosphate and 4 bases
PURINE BASES2 rings each having 2 H+
PYRIMIDINEa single ring having 2 H+
NUCLEOTIDE STRUCTUREcomposed of one base, a sugar and a PHOSPHATE GROUP forms a phosphoester bond with C5'
NUCLEOSIDES STRUCTUREcomposed of one base and one sugar, either deoxyribose or ribose, forms a glycosidic bond C1'
DNA COMPLIMENTARY PAIRSadenine pairs with thymine; guanine paired with cytosine
RNA COMPLIMENTARY PAIRSadenine pairs with uracil; gaunine pairs with cytosine as in DNA
REPLICATIONprocess of duplicating DNA by pairing the bases on each parent strand with their complementary bases
TRANSCRIPTIONtransfer of genetic material from DNA by the formation of mRNA
TRANSLATIONinterpretation of the codons in mRNA as amino acids in a peptide



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