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Calcium regulation & Bone repair

AB
Bones store99% of calcium
9-11 mg/100ml of bloodcalcium levels in body
breathing may cease ifCa+ too low in blood
heart may stopif Ca+ too high in blood
enzymes need as a cofactorCa+ ions
parathyroid hormonereleased if levels Ca+ are low
osteoclasts increase bone resorptionif PTH is released
calcitriolactive form of vitamin D
thyroid gland releasescalcitonin
calcitonininhibits osteoclasts activity
calcitonin promotesbone formation
calcitonin released whenCa+ levels are too high
fracture hematomablood clot around fractured bone
loss of blood causesbone cells to die
procallushematoma forms granulation tissue
fibroblasts invadeprocallus
chondroblasts develop inavascular areas
fibrocartilagedevelop in avascular areas of broken bone
fibrocartilaginous calluswhen fibrocartilage forms through fracture
osteoblasts produce spongy bonein vascularized areas
fibrocartilage converted to spongy bonein bony callus
compact bonereplaces spongy bone in fracture
thickened areafound around fracture area
lack of estrogencauses bone loss
resorption outpaces bone formationosteoporosis


Mrs. Cheshire

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