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Pathophysiology: Hematology Flash Cards

AB
Platelet count150,000 - 400,000 microL
The Intrinsic and Extrinsic Pathways end hereActivation of Factor X
What is the initiating factor for a clot?Endothelial Injury
Which electrolyte is necessary for clotting?Calcium
Thrombocytopenia<100,000 microL
Oral Contraceptives have what effect on coagulability?Increase coagulability
Which organ synthesizes most clotting factors?Liver
ThrombocytosisPlatelet count > 1,000,000 microL
Pinpoint bleeding associated with platelet deficitsPetechiae
Larger areas of bruising associated with platelet deficitsPurpura
Immune Thrombocytopenic Purpura (ITP) cause?Autoimmune disorder where antibodies for against platelets
Autosomal domininat trait causing coagulation deficiencyvon Willebrand Disease
Coagulation disorder affecting primarily males. Deficiency in Factor XIII.Hemophilia A
Cancer, Infections, Obstetric Complications, Shock, Trauma, and Vessel damage are all conditions that precipitate?DIC (Disseminated Intravascular Coagulation)
Too many RBC is called?Polycythemia
Too few RBC is called?Anemia
Normal average Hemoglobin12 - 18 g/ dL
A mineral necessary for hemoglobin synthesisFe (Iron)
Hormone released by kidney in response to tissue hypoxiaErythropoietin
What type of bilirubin causes jaundice?Unconjugated
How are destroyed RBCs removed from the system?via liver and spleen
Chest pain, dizziness, increased heart rate, shortness of breath, pallorManifestation of anemia
Type of Hemolytic Anemia that affects HbS?Sickle Cell Disease
What type of anemia is manifested by spoon shaped fingernails and picaIron Deficiency
What is pernicious anemia?Lack of intinsic factor cuasing inability to absorb B12
Which anemia is the only one known to cause neurologic symptoms?B12 Anemia
Which vitamin has been shown to help prevent neural tube defects?Folic Acid (a B vitamin)
Which of the following would most likely experience chronic anemia: A patient with renal failure; a smoker; or alcoholic?A patient with renal failure (they don't make enough erythropoietin)
What type of anemia has decreased RBCs, WBCs and Platelets?Aplastic Anemia
What do we call low RBCs, WBCs, and Platelets?Pancytopenia
Polycythemia puts a patient at risk for?Clots
What is Kernicterus?An excessive accumulation of bilirubin in the brains of infants
As we age do our hemoglobin levels - increased? or decreased?Decreased
What is a normal WBC?4,000 - 10,000 cells/ mcg:
Neutropenia versus Agranulocytosis?< 1500 cells/ mcgL (neutropenia); <200 cells/ mcgL (agranulocytosis)
What causes mononucleosis?Epstein Barr Virus
Can EBV (Epstein Barr Virus) lead to the development of cancer?Yes
Which Lymphoma has Reed Sternberg Cells?Hodgkin's Disease
Classified by cell type and onset/durationLeukemia
Cancer of the B cells. Bence Jones proteins are readily excreted. Signficant bone pain.Multiple Myeloma



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