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Pathophysiology: IMMUNE

AB
InterleukinsCommunicate between cells. Play a role in inflammation and immune responses.
Interferons"interfer" with viral replication. Activate NK (Natural Killer) cells.
Tumor Necrosis Factor (TNF)Activates neutrophils and endothelial cells. Induces inflammation. Kills cells through apoptosis.
Growth FactorSimulates production of plasma cells.
Natural Killer (NK) cellsCan destroy tumor cells or virus infected cells without previous exposure
Phagocytic CellsNeutrophils and Macrophages
Presenter cellsMacrophages and Dendrites
The first line of defensePhysical barriers like skin, mucous membranes, GI tract mucous
Innate ImmunityAn immune response not specific to the type of invader.
Humoral ImmunityB cells
Cell Mediated ImmunityT cells
CD4Stimulates B and T cells. Activates T cell response.
T suppressor cellHelps decrease immune responses.
ThymusWhere T cells mature.
Bone marrowWhere B cells mature.
ImmunoglobulinsB cells that have matured.
IgGMost common immunoglobulin also crosses placenta.
IgMFirst immunoglobulin on the scene.
IgEImmunoglobulin seen in allergies.
IgAFound in secretions like breast milk.
HLA (Human Leukocyte Antigen)Recognizes self from non-self.
Adaptive ImmunityRecognizes self from non-self. One antigen to one antibody.
Titer or serologyPresence of antibodies
Passive ImmunityTemporary immunity
SeroconversionPoint where person tests positive for antibodies.
Window periodPoint from inital infection to when patient tests positive for HIV antibodies.
CD4Cell that HIV attacks.
Diagnostics for HIV/ AIDsELISA, Western Blot, PCR
CD4 < 200 cellsNow AIDs
Opportunistic InfectionsPCP, TB, CMV, Karposi's Sarcoma
Type I Hypersensitivity ReactionAllergies
Type II Hypersensitivity ReactionCytotoxic - Incompatible blood types.
Type I Hypersensitivity ReactionIgE, mast cells, basophils
Type II Hypersensitivity ReactionIgG, IgM
Type III Hypersensitivity ReactionAntigen-Antibody Complexes that cause tissue damage.
Type III Hypersensitivity ReactionPost strep glomerulonephritis
Type IV Hypersensitivity ReactionCell mediated
Type IV Hypersensitivity ReactionPoison ivy, TB test
Latex allergyIgE or T cell mediated. Reaction to protein in Latex.
Bananas, Kiwis, Avocados, TomatoesCross sensitivity to Latex.



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