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Mechanism of Defense: Inflammation

AB
BradyininReleased from injured cells-activates pain receptors
HistamineChemical mediator that cause vasodilation and increased capillary permeability
Local signs of inflammationErythema; warmth; edema; pain; loss of function
ErethyemaRedness
EdemaIncreased fluid in interstitial area
Systemic signs of inflammationFever; malaise; fatigue; headache; anorexia
MalaiseGeneral feeling of being unwell; uneasiness; discomfort
AnorexiaLoss of appetite
ExudateCollection of fluid in the area of inflammation
Serous exudateFluid with protein and WBC's; typically clear; common with allergies and burns
Fibrinous ExudateThick; sticky; higher number of cells and fibrin
PurulentThick; yellow-green discharge; contains debris and microorganisms; common with infection; PUS
SanguinousBloody discharge
Inflammatory Diagnostic testsCBC; C-reactive protein (CRP); Erythrocyte sedimentation rate (ESR);
Chronic inflammationDevelops slowly and lasts longer; less swelling but more tissue destruction and scar formation
Treatment of inflammationRICE: rest; ice;compress;elevate
Complications of Scar formationLoss of function; contractures; obstructions; adhesions; hypertrophic scarring; ulceration; stenosis
Scar tissueNon-elastic



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