| A | B |
|---|
| membrane structure is known as the ___ | fluid mosaic model |
| membrane structure is ____ | trilaminar |
| draw the membrane structure | lipid bilayer with embedded proteins |
| length of the lipid bilayer in the membrane structure from lipid hydrophilic head to opposing lipid hydrophilic head | 5 nm |
| what are the 3 components of the membrane? | lipids, other hydrophobic molecules, proteins |
| draw phosphatidyl-choline | polar hydrophilic head with (choline, phosphate, glycerol), straight hydrocarbon tail, kinked hydrocarbon tail |
| draw phosphatidyl-serine | p. 104 in notes |
| draw phosphatidyl-ethnolamine | p. 104 in notes |
| the phospholipid bilayer is lipid soluble so it is ____ and ____ | hydrophobic and nonpolar |
| lipids added to one side of the membrane via ____ get to the other | flipase |
| glycolipids may be found on the outside _____ making the cell slippery | extracellular leaflet |
| _____ on the inner leaflet, involved in recognition during cell death, apoptosis | phosphatidylserine |
| _____ is involved in 2nd messenger signalling | phosphatidylinositol |
| cells programmed to die, new cells should equal old cells | apoptosis |
| when phosphatidyl serine moves from the ____ to the ____ this is recognized by other cells and ____ cells are _____ to the _____ to be ______. | intracellular leaflet, extracellular leaflet, apoptotic cells, endocytosed, lysosome, broken down and recycled |
| cholesterol is a _______ molecule | hydrophobic |
| Integral membrane proteins are anchored by the hydrophobic center of the membrane. These are _____ proteins or _____ proteins | transmembrane, lipid linked |
| ______ can pass through the membrane | hydrophobic alpha helix |
| ______ membrane proteins - anchored by association with other proteins | peripheral |
| Peripheral membrane proteins are held strongly and can be dissociated with ____ | salts or detergents |
| 3 strategies of transmembrane proteins crossing the membrane | 1. segment of alpha helix with all hydrophobic AA s, 2. a group of amphipathic alpha helices, 3. beta barrels |
| Lipid linked: ____ tethered to a ____ | protein, lipid |
| length of the lipid can dictate how | strongly protein is held in membrane, longer is tighter |
| what side of the protein is in the extracellular space in a lipid linked integral membrane protein? | N terminus |
| ____ involved in signaling have long lipids and remain in the membrane | G-Proteins |
| some integral membrane proteins can be pulled out and put in they are short ___ | ARF |
| ARF | ADP Ribosolation Factor |
| a great place to hide ARF is | inside the membrane of soluble protein is hydrophobic ???? |
| in response to signal ARF changes- disposes lipid and inserts into a membrane where it organizes a vesicle to pinch off. Then ARF returns to original conformation, pulls lipid out of membrane making ARF ___ again | soluble |
| peripheral membrane proteins are anchored by ____ | association with other proteins (on both sides of the membrane, extra and intra cellular) |
| red blood cells have a _____ morphology | biconclave |
| the plasma membrane is reinforced in the inside is the cell cortex, the reinforcement on the inside is with | spectrin |
| in the plasma membrane, spectrin attaches to attachment proteins in the membrane in areas called ____ | focal adhesions |
| cells can confine lipids and proteins to specific areas in the ____ | membrane |
| gut epithelia (cell lining) have 2 areas: | 1. apical (faces lumen) 2. basalateral (cover lateral and base regions) |
| apical and basalateral regions separated by protein that causes a ____ | tight junction impermeable to water |
| specific ____ and ____ can be restricted to only ___ or ____ regions | proteins, lipids, apical, basalateral |
