| A | B |
|---|
| Allograft | Grafts between members of the same species; different genotypes and HLA; can be living donor or cadaver) |
| Isograft | Occurs when donor and recipient are identical twins |
| Histocompatibility | Ability of cells to survive transplantation without immunological interference by recipient |
| Heterograft | Also called xenograft; tissue used from another species for a temporary graft |
| Azathiopruine (Imuran) | Immunosuppressive agent/cytotoxic: monitor WBC and platelet count |
| Cyclosporin (Sandimmune, Neoral) | Immunosuppressive agent/cytoxic: also neprhotoxic |
| OKT3 (Orthoclone) | Monoclonal antibody: potential for anaphylaxis; pre-medicate |
| ATG (Atgam) | Antilymphocyte globulins; made from horse serum; potential sensitivity |
| Hyperacute rejection | Pre-existing antibodies to donor ABO or HLA antigens; transplant lost |
| Acute rejection | Primarily cell-mediated immune response to HLA antigens; treat with OKT3 |
| Chronic rejection | Probable antibody-mediated response; eventual kidney loss |
| Accelerated rejection | Pre-existing antibodies to donor ABO or HLA; within week of transplant; transplant fails |
