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Biochemistry Board Review (Orange) - pyruvate deh complex, krebs, ETC

AB
Pyruvate dehydrogenase complex occurs in themitochondrial matrix
Pyruvate dehydrogenase complex reaction isoxidative decarboxylation (NADH is produced and CO2 is lost)
Pyruvate dehydrogenase complex is stimulated byinsulin
Pyruvated dehydrogenase complex is inhibited byglucagon
Pyruvate dehydrogenase coenzymesNAD+, FAD+, thiamine pyrophosphate, lipolic acid, CoA
Mitochondrial matrix is the location of thekrebs cycle
eight steps in theTCA cycle
Regulatory enzymes of the krebs cyclecitrate synthase, isocitrate dehydrogenase, alpha-ketoglutarate dehydrogenase complex
Per turn of the TCA cycle (1 acetyl-CoA) =12 ATP
Per molecule of glucose oxidized (2 acetyl-CoA) =24 ATP
Krebs cycle 3 NADH = (via ETC)9 ATP
Krebs cycle 1 FADH2 = (via ETC)2 ATP
Krebs cycle 1 GTP = (via substrate level phosphorylation)1 ATP
Krebs cycle total =12 ATP
Synthesis of ATP in the ETC is referred to asoxidative phosphorylation
Location of the ETCinnermitochondrial memebrane
ETC - produces 3 ATPNADH
ETC each NADH results in # protons pumped out6 protons
ETC - produces 2 ATPFADH2
ETC each FADH2 results in # protons pumped out3 protons
Ultimate acceptor of electrons in the ETCoxygen
Componenet of the ETC and has a simular structure to vitamin KCoenzyme Q
Couples the ETC to the synthesis of ATPchemiosmotic hypothesis or mitchell hypothesis
Blocks the ETCcyanide and carbonmonoxide

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