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Renal Endocrine I

Overview of basic hormonal mediators derived from or active on the kidney.

AB
Source of aldosteroneAdrenal cortex and zona glomerulosa
Action(s) of aldosteroneRenal sodium retention with potassium and proton wasting
Signal(s) to release aldosteroneAdrenocorticotropic hormone (ACTH)
Effect of sodium retention by aldosteroneVolume expansion & increased blood pressure
Source of cortisolAdrenal cortex
Action(s) of cortisolMediate blood glucose level
Signal(s) to release cortisolAdrenocorticotropic hormone (ACTH) & corticotropin-releasing factor (CRF)
Less cortisol production during this timeNight
More cortisol production during this timeMorning
Source of angiotensinogenLiver
Product of angiotensinogen conversionAngiotensin I
Converter of angiotensinogen to productRenin
Product of angiotensin I conversionAngiotensin II
Converter of angiotensin I to productAngiotensin Converting Enzyme (ACE)
Organ that produces angiotensin converting enzymeLung
Action(s) of angiotensin IIVasoconstriction & aldosterone release
Source of reninJuxtaglomerular cells of kidney
Signal(s) to release reninHigh potassium; low sodium; decreased afferent renal arteriole pressure
Inhibitor(s) of renin releaseLow potassium
Action of reninConverts angiotensinogen to angiotensin I
Source of vasopressinNeurohypophysis (posterior pituitary)
Signal(s) to release vasopressinIncreased blood osmolarity; pain; vascular stretch feedback
Inhibitor(s) of vasopressin releaseHypo-osmolarity
Action(s) of vasopressinvasoconstriction; free-water retention by renal tubules
Source of calcitriolKidney
Action(s) of calcitriolElevate blood calcium by activating osteoclasts and elevating calcium binding protein in the gut
Source of calcitoninThyroid parafollicular (C) cells
Signal(s) to release calcitoninLow blood calcium
Inhibitor(s) of calcitonin releaseHigh blood calcium
Action(s) of calcitoninDecrease blood calcium by inhibiting osteoclasts; Causes phosphate wasting by kidney


Erik Van Eaton

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